The Amoeba is here! (and How To Play Pathogenic with Friends!)
Hey Parasites!
We are going into Next Fest with an update! Invade the human body with the shapeless Amoeba, experiment with new organelles, and more!
New Pathogen: Amoeba

The Amoeba is our latest playable pathogen in the demo. Unlike other parasites, it has no defining shape – literally just start out as a tiny blob of 3 organelle slots. While this gives the Amoeba a tougher start (tip: get stash slot upgrades for extra organelles), players will be able to add new organelle slots as the Amoeba levels up.
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This means the Amoeba can grow into unique shapes to suit your specific builds. There are some restrictions in place to make sure it doesn’t break the game, but otherwise the layout and playstyle of the Amoeba are totally up to you.
New Organelles
In addition to the Amoeba, we’re adding new organelles for you to play with!

- Chromatophore Lens: Charge and activate to release a deadly laser beam

- Trophic Pseudopod: The first of pseudopods, a new type of organelles that automatically reach for the closest enemy to damage them and activate unique effects. This one in particular provides overcharge.

- Ballistic Flagellum: Shoot down your pursuers as you sprint or dash away. Perfect for kiting. This screenshot might exaggerate things a bit though – a Triosome is attached to multiply the projectiles.
Challenges
We know plenty of you have already played the 4 demo levels tens or maybe even hundreds of times. While new levels will have to wait for the full game, we do have a new challenge mode to spice things up for you.

In the starting loadout, you can now select challenges that modify your runs with special conditions. The demo currently has 4 of these new challenges to put your skills to the test. Do you have what it takes to conquer them all?
And before we go to the changelog, just want to remind you that Pathogenic has a local co-op mode to play with friends! While we don’t have online multiplayer, you can connect remotely by using Steam’s Remote Play Together function. Here's our video guide to setting it up:
And that concludes our new patch! Hope you all enjoy playing and shaping the Amoeba with all the new content. Join our Discord to chat about tips and feedback for Pathogenic, and remember to keep an eye on our socials for the latest news on our game!
Full Changelog
As usual, this update also contains a range of improvements, fixes, and balancing changes. See below for the full changelog:
Main Changes
- Added the Amoeba playable parasite
- Added 4 challenges to modify your run with
- Added 3 new organelles: Trophic Pseudopod, Ballistic Flagellum, Chromatophore Lens
- Added a separate plasmid map for the Diatom
- Added blood stream flows to the veins connecting rooms
- *Added ???*
Improvements
- Shaders now pre-cache on startup (with a loading screen) to cut in-game stutter
- Steam Workshop / mod support added
- Japanese and Korean localization added, Turkish coming this week
Balance Changes
Player
- Dodge cooldown reduced: 1.3s → 1.2s
- Taking a hit and entering a room grants a slightly longer invulnerability window
Organelles
- Bacteriophage Launcher: damage now scales with rarity; stamina cost 20 → 25; spawned minions have less HP
- Nidublast: damage 16 → 20; spawned minions have less HP
- Pyroflagellum: damage reduced
- Rotary Extruder: stamina cost reduced (0.7 → 0.3)
- Cluster Ejector: stamina cost 5 → 6
- Oxidator: now applies a burn-on-hit (doubled at Epic+ rarity)
- Dorsal Lysosome: backstab damage bonus reduced
- Echosome: splash damage slightly reduced
- Triosome: charge damage bonus slightly reduced
- Elusive Mitochondrion: detection area is now much bigger and is easier to trigger
- Entrant Mitochondrion: charge duration reduced at higher rarities
- Metabolic Mitochondrion: charge duration 2.5s → 2.0s
- Regenerator: heals slightly less often
- Mutagen: produces DNA slightly slower
- Ossificator: armor builds slightly slower at higher rarity
Enemies
- B-Cell HP: 900 → 750
- Dendritic Cell HP: 1400 → 1000
- T-Cell speed buff reduced
Mutations
- RNA Retriggering removed from the random mutation pool (still available as a reward)
- Additive Momentum reworked: bonus now scales off lash thrust instead of your movement speed
Fixes
- Out-of-bounds recovery: players or bosses stuck in walls are detected and pushed back into the room
- Degenerate levels regenerate instead of crashing
- Every floor now reliably has a shop
- Many crash and stability fixes
- Performance optimizations
- Leaderboard fix
